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Medication refill calls are handled between 9 am and 4 pm. After hours medication-related calls including prior authorization or pharmacy changes will be answered on the following business day. Please allow a minimum of three business days for your refill to be processed.

Lipotropics, Metabolizing Fat and Weight Loss

The term lipotropic literally means “fat-loving”! Lipotropic agents are a class of substances that play an important role in your body’s use of fat. Many substances have lipotropic properties, the most noteworthy of which are choline, inositol and methionine. Through their involvement in lipid (fat) metabolism, lipotropics help maintain a healthy liver by:

1. Increasing lecithin production by the liver. The term refers to substances that help the liver metabolize fats and carbohydrates, which helps to solubilize cholesterol, thus lessening cholesterol deposits in blood vessels and decreasing gallstone formation (gallstones are made of cholesterol).

2. Preventing the accumulation of fats in the liver. A fatty liver can cause sluggish liver function.

3. Detoxifying amines (byproducts of protein metabolism). This is important for people on high-protein diets.

4. Increasing resistance to disease. Lipotropics bolster the thymus gland to carry out its anti-disease function by stimulating the production of antibodies. Stimulating the growth of phagocytes, which surround and absorb invading viruses and microbes. They also recognize and destroy foreign and abnormal tissue.

That’s why we recommend weekly lipotropic injections to help you lose weight. In most cases, you will look and feel better after just four weeks of injections. Your individual results may vary.

What are the most important functions of individual lipotropics?

Choline and inositol are co-enzymes required for the proper metabolism and removal of fat from the liver. Choline works well with inositol to utilize fats and cholesterol. The body can produce choline, with the help of vitamin B12, folic acid and methionine.

Choline: Metabolizes fat. Deficiency of choline can lead to cirrhosis and fatty degeneration of the liver and hardening of the arteries (arteriosclerosis). It is being used today for ailments such as gallbladder trouble, diabetes, muscular dystrophy, glaucoma, senility and memory problems (forgetfulness). Choline detoxifies amines that are the byproducts of protein metabolism.

Inositol: Deficiency can lead to hair loss. Inositol works with vitamin E to facilitate its actions in the treatment of muscular dystrophy. It is used in nerve and muscle disorders such as multiple sclerosis and cerebral palsy. Caffeine may cause depletion of inositol.

Methionine: Works with choline to detoxify amines, which are the byproducts of protein metabolism. It acts as a catalyst for choline and inositol function. Along with choline, it helps reduce liver fat and protects the kidneys.

Hydroxocobalamin (1000 mcg) B12

This is a unique form of vitamin B12 that offers longer-lasting effects than the common cyanocobalamin form. Vitamin B12 is needed for normal fatty acid and DNA synthesis. It is essential for maintaining the integrity of the nervous system and the synthesis of molecules involved in the production of energy. Vitamin B12 deficiency can result in fatigue, cognitive impairment, neuropathies and sleep disorders. Hydroxocobalamin is the most potent form of vitamin B12 found in nature and the only active form in the brain outside the mitochondria. We need hydroxocobalamin for the healthy development and sustenance of our circulatory, immune and nervous systems.

Generally, patients experience a boost of energy and alertness after a B12 injection. Hydroxocobalamin is believed to improve brain and nervous system function, detoxification and oxidative stress within the body. This version of B12 also plays a key role in sleep. It helps the brain fill up its neurotransmitter “gas tank” when neurotransmitters are produced from amino acids. Hydroxocobalamin differs from the most commonly found commercial version of vitamin B12, which is cyanocobalamin. Cyanocobalamin is a synthetic, inactive form of vitamin B12 that must undergo several metabolic processes before it leads to any benefit for the patient. This can be problematic in people with certain deficiencies and health issues. Unfortunately, this is the most common form of vitamin B12 on the market and is found in most vitamin B-complexes.


Lipotropic nutrients are compounds that promote the flow of fat and bile to and from the liver. They produce a “decongesting” effect on the liver and promote improved liver function and fat metabolism. Lipotropic substances decrease fat deposits or speed the removal of fat within the liver. Lipotropic mixtures combine liver and gallbladder therapies in one product, and those using it can benefit simultaneously from the power and potential of them all. Lipo-Plex contains methionine, inositol, choline, pyridoxine (B6), dexpanthenol (B5) and hydroxocobalamin (B12).

Vitamin B12 Injections Cost

  • $20 for a single injection
  • $60 for 4 injections

Lipo-B Injections Cost

  • $25 for a single injection
  • $75 for 4 injections

Good overall experience every time, even if I have to wait,. I know Dr Klim will give me the time he gives his other patients when they need it.
-- L.O

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18077 River Road, Suite 200, Noblesville, IN 46060

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Peter Klim, DO, MS, is the medical director of Medical Pain & Spine Care of Indiana, specialists in the most advanced interventional pain treatments available, located at 18077 River Road, Suite 200, in Noblesville, IN 46060. Dr. Klim and his team help people from all over Noblesville, Westfield, Fishers, Carmel, Indianapolis and the surrounding Indiana communities. Call 317-776-7028 for an appointment.